• Internal medicine · Feb 2022

    Case Reports

    Paradoxical Formation of a Pleuroparenchymal Fibroelastosis-like Lesion in the Chronic Course of Pulmonary Sarcoidosis.

    • Michiru Sawahata, Takeshi Johkoh, Takeshi Kawanobe, Chiyoko Kono, Takuji Suzuki, Masashi Bando, Koichi Hagiwara, Noriharu Shijubo, Satoshi Konno, and Tetsuo Yamaguchi.
    • Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
    • Intern. Med. 2022 Feb 15; 61 (4): 523-526.

    AbstractWe herein report the long-term changes in chest computed tomography (CT) findings from early sarcoidosis lesions to pleuroparenchymal fibroelastosis (PPFE)-like lesions in a 30-year-old man with granulomas on a transbronchial lung biopsy. Multiple bilateral micronodular and nodular opacities around the bronchovascular bundle in the upper lobes detected by chest CT in 2004 disappeared, but paradoxically, peripheral consolidations continued to grow at the periphery of the original lesions. Chest CT in 2017 confirmed the progression of bilateral shrinkage of the upper lobe, spread of peripheral consolidations and wedge-shaped opacities below the first rib, and bronchiectatic air bronchograms, confirming PPFE-like lesions.

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