• Li Zhou, Tian-wu Chen, Xiao-ming Zhang, Zhi Yang, Hong-jie Tang, Dan Deng, Nan-lin Zeng, Li-ying Wang, Xiao-li Chen, Hang Li, Chun-ping Li, Li Li, Xian-yong Xie, and Jiani Hu.
• Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
• J Magn Reson Imaging. 2014 Apr 1; 39 (4): 872-8.

PurposeTo determine whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could monitor progression of liver fibrosis in a piglet model, and which DCE-MRI parameter is most accurate for staging this disease.Materials And MethodsSixteen piglets were prospectively used to model liver fibrosis and underwent liver DCE-MRI followed by biopsy on the 0, 5th, 9th, 16th, and 21st weekends after modeling of fibrosis. Time of peak (TOP), time to peak (TTP), positive enhancement integral (PEI), maximum slope of increase (MSI), and maximum slope of decrease (MSD) were measured and statistically analyzed for the monitoring and staging.ResultsAs fibrosis progresses, TOP and TTP tended to increase, whereas MSI, MSD, and PEI tended to decrease (all P < 0.05). TOP, TTP, and MSI could discriminate fibrosis stage 0 from 1-4, 0-1 from 2-4, 0-2 from 3-4, and 0-3 from 4; PEI could distinguish the above-mentioned stages except 0-3 from 4; and MSD could distinguish stage 0-3 from 4, and 0 from 1-4 (all P < 0.05). For predicting stage ≥1, ≥2, and ≥3, the area under receiver operating characteristic curve (AUC) of MSI was largest among all parameters; for stage 4 AUC of TTP was largest.ConclusionDCE-MRI has the potential to dynamically stage progression of liver fibrosis.Copyright © 2013 Wiley Periodicals, Inc.

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