• Stroke · Oct 2010

    Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy.

    • Xiang Fan, Zhanyang Yu, Jianxiang Liu, Ning Liu, Katherine A Hajjar, Karen L Furie, Eng H Lo, and Xiaoying Wang.
    • Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
    • Stroke. 2010 Oct 1; 41 (10 Suppl): S54-8.

    AbstractHemorrhagic transformation, incomplete reperfusion, neurotoxicity, and the short treatment time window comprise major challenges for thrombolytic therapy. Improving tissue plasminogen activator therapy has become one of the highest priorities in the stroke field. Recent efforts have been aimed at identifying new strategies that might enhance the thrombolytic efficacy of tissue plasminogen activator at the same time as reducing its associated complications related to hemorrhage and neurotoxicity. We believe that the combination of low-dose tissue plasminogen activator with recombinant annexin A2 (a tissue plasminogen activator and plasminogen coreceptor) might constitute a promising approach. Our pilot study using a focal embolic stroke model in rats supports this hypothesis.

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