• Clin Orthop Surg · Sep 2016

    Case Reports

    Intra-Articular Pigmentation of Synovium: An Unusual Cause.

    • Shobhit Verma, Steven Hamilton, and Sue M Liew.
    • Department of Trauma and Orthopaedics, The Alfred, Melbourne, Australia.
    • Clin Orthop Surg. 2016 Sep 1; 8 (3): 330-2.

    AbstractAn unusual grayish brown discoloration of the synovium was found during a knee arthroscopy of a 72-year-old man. He also had similar pigmentation affecting the skin on the legs, arms, hands, and face. It was found he had been taking 400 mg of amiodarone hydrochloride daily for last 7 years. Amiodarone is known to cause a slate grey pigmentation of skin and cornea, but we believe this is the first report of amiodarone-induced pigmentation of the synovium. The arthroscopist should be aware of the possibility of drug-related synovial pigmentation and include this in differential diagnosis.

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