• María Serrano-Alonso, Paloma Martín-Moreno, Gregorio Rábago, Francisco Guillén-Grima, José I Herrero, and Mirian Fernández-Alonso.
• Servicio de Farmacia, Clínica Universidad de Navarra, Pamplona, España.
• Med Clin (Barc). 2022 Jun 10; 158 (11): 543-546.

Background And ObjectiveWe compared the efficacy and safety of standard vs. extended primary cytomegalovirus (CMV) prophylaxis in solid organ transplantation.Materials And MethodsRetrospective cohort study of CMV seronegative recipients who received CMV prophylaxis after solid organ transplantation from seropositive donor (D+/R-) (2007-2017). CMV infection in the first two years after transplantation in recipients with prophylaxis longer or shorter than 100 days were compared.ResultsCMV infection occurred in 29 of 66 patients (43.9%) with prophylaxis. Forty-five patients (68.2%) received extended prophylaxis. CMV infection and disease rates were not different between patients with extended and standard prophylaxis. However, extended prophylaxis was associated with a higher rate of myelotoxicity (68.9% vs. 42.9%, p<0.05).ConclusionsExtending primary CMV prophylaxis over 100 days did not prevent late-onset infection but it was associated with hematological toxicity.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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