• Carlo Genovese, Sergio Davinelli, Katia Mangano, Gianna Tempera, Daria Nicolosi, Salvatore Corsello, Franca Vergalito, Edoardo Tartaglia, Giovanni Scapagnini, and Roberto Di Marco.
• a Department of Biomedical and Biotechnological Sciences , University of Catania , Catania , Italy.
• J Chemother. 2018 Apr 1; 30 (2): 107-114.

AbstractUrinary tract infections (UTIs) are an economic burden for public health. The increasing prevalence of resistant bacteria which cause UTIs may be related to the inappropriate prescription of antibiotics. The aim of this preliminary study was to evaluate whether three different combinations of plant extracts plus d-mannose are effective in preventing the recurrence of UTIs. Three groups of patients received three combinations of plant extracts in conjunction with d-mannose. These were: berberine, arbutin and birch (group A); berberine, arbutin, birch and forskolin (group B); and proanthocyanidins (group C). The clinical recurrence of cystitis at the end of treatment and during follow-up was determined by comparison with baseline measurements using the microbiological assessment of urine samples, vaginal swabs and vaginal smear slides. Patients in groups A and B had a lower incidence of episodes of recurrent cystitis during treatment and follow-up, samples with a significantly lower median bacterial load and a reduction of the grade of lactobacillary flora compared to patients in group C.

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