• Eur. J. Clin. Microbiol. Infect. Dis. · Oct 1996

    Multicenter Study

    Fluconazole monotherapy for cryptococcosis in non-AIDS patients.

    • H Yamaguchi, H Ikemoto, K Watanabe, A Ito, K Hara, and S Kohno.
    • Teikyo University Research Center for Medical Mycology, Japan.
    • Eur. J. Clin. Microbiol. Infect. Dis. 1996 Oct 1; 15 (10): 787-92.

    AbstractTreatment with 200 to 400 mg/day fluconazole was evaluated in 44 patients without AIDS who had cryptococcosis (19 with cryptococcal meningitis, 22 with pulmonary cryptococcosis, 3 with other cryptococcal infections). For all patients, the clinical response rate was 89% (48% were clinically cured and 41% clinically improved). Of the patients with cryptococcal meningitis, 89% were mycologically cured. These rates are comparable to those obtained in the treatment of AIDS patients with cryptococcal disease. In the group of patients with cryptococcal meningitis, there was a high rate of agreement between the mycological response to therapy and cryptococcal antigen test results. The use of cryptococcal antigen testing is recommended in all patients with cryptococcosis.

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