• Phytomedicine · Mar 2019

    Review

    Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis.

    • Bahare Salehi, Elena Maria Varoni, Mehdi Sharifi-Rad, Sadegh Rajabi, Paolo Zucca, Marcello Iriti, and Javad Sharifi-Rad.
    • Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    • Phytomedicine. 2019 Mar 1; 55: 125-136.

    BackgroundThe plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery.PurposeIn this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity.ConclusionAmong the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.Copyright © 2018 Elsevier GmbH. All rights reserved.

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