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Clinical Trial
A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination.
- Stefan Handtke, Martina Wolff, Carlo Zaninetti, Jan Wesche, Linda Schönborn, Konstanze Aurich, Lena Ulm, Nils-Olaf Hübner, Karsten Becker, Thomas Thiele, and Andreas Greinacher.
- Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
- Blood. 2021 Jul 1; 137 (26): 3656-3659.
AbstractVaccination is crucial in combatting the severe acute respiratory syndrome coronavirus 2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activating antibodies directed against platelet factor 4 (PF4). We present a widely applicable whole-blood standard flow cytometric assay to identify the pathogenic antibodies associated with vaccine-induced immune-mediated thrombotic thrombocytopenia (VITT) after ChAdOx1 nCov-19 vaccination. This assay will enable rapid diagnosis by many laboratories. This trial was registered at www.clinicaltrials.gov as #NCT04370119.© 2021 by The American Society of Hematology.
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