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Nature reviews. Cancer · Apr 2015
ReviewTriple-negative breast cancer in African-American women: disparities versus biology.
- Eric C Dietze, Christopher Sistrunk, Gustavo Miranda-Carboni, Ruth O'Regan, and Victoria L Seewaldt.
- 1] Duke University, Durham, North Carolina 27710, USA. [2].
- Nat. Rev. Cancer. 2015 Apr 1; 15 (4): 248-54.
AbstractTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.
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