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Comparative Study
Furosemide and mannitol in the treatment of acute experimental intracranial hypertension.
- H A Wilkinson and S R Rosenfeld.
- Neurosurgery. 1983 Apr 1; 12 (4): 405-10.
AbstractIntracranial hypertension was induced in dogs and a small number of baboons by the inflation of epidural balloons. The resulting increased intracranial pressure (ICP) was treated with standard clinical doses of furosemide (0.7 mg/kg), "mini" doses of mannitol (0.75 g/kg), or both agents in combination. Mannitol consistently and rapidly reduced ICP in all animals. When results were averaged, furosemide used alone caused a slow reduction in ICP, but the results were variable in individual animals--with ICP actually increased in some. When furosemide and mannitol were given together, the ICP fell rapidly and remained low for considerably longer than after either agent alone.
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