• Psychiatr. Clin. North Am. · Sep 2018

    Review

    Deep Brain Stimulation in Psychiatry: Mechanisms, Models, and Next-Generation Therapies.

    • Mustafa Taha Bilge, Aishwarya K Gosai, and Alik S Widge.
    • Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA.
    • Psychiatr. Clin. North Am. 2018 Sep 1; 41 (3): 373-383.

    AbstractDeep brain stimulation has preliminary evidence of clinical efficacy, but has been difficult to develop into a robust therapy, in part because its mechanisms are incompletely understood. We review evidence from movement and psychiatric disorder studies, with an emphasis on how deep brain stimulation changes brain networks. From this, we argue for a network-oriented approach to future deep brain stimulation studies. That network approach requires methods for identifying patients with specific circuit/network deficits. We describe how dimensional approaches to diagnoses may aid that identification. We discuss the use of network/circuit biomarkers to develop self-adjusting "closed loop" systems.Copyright © 2018 Elsevier Inc. All rights reserved.

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