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- Sergiusz Józwiak, Karen Stein, and Katarzyna Kotulska.
- Department of Neurology & Epileptology, The Children's Memorial Health Institute, 04-730, Warsaw, Poland. sergiusz.jozwiak@gmail.com
- Future Oncol. 2012 Dec 1; 8 (12): 1515-23.
AbstractEverolimus (RAD001), a mTOR inhibitor, was initially used as an immunosuppressant in organ transplant patients; however, it also has significant antineoplastic properties. In patients with subependymal giant cell astrocytomas (SEGAs) associated with tuberous sclerosis complex who are not candidates for surgery, single-agent everolimus has demonstrated the ability to significantly reduce SEGA volume with good tolerability. In the Phase III, randomized, placebo-controlled trial, everolimus was associated with a SEGA response rate of 35% compared with 0% in the placebo group. The most common adverse events in clinical trials were stomatitis/mouth ulceration and upper respiratory tract infections, and most adverse events were grade 1 or 2; grade 4 events were rare.
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