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J. Clin. Microbiol. · Jun 1998
Randomized Controlled Trial Clinical TrialPositive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis.
- A Kokkola, H Rautelin, P Puolakkainen, P Sipponen, M Färkkilä, R Haapiainen, and T U Kosunen.
- Second Department of Surgery, Helsinki University Central Hospital, Finland.
- J. Clin. Microbiol. 1998 Jun 1; 36 (6): 1808-10.
AbstractPatients with atrophic corpus gastritis and elevated Helicobacter pylori antibody titers but 13C-urea breath test (13C-UBT) and histology results negative for H. pylori were randomized into eradication therapy or follow-up only. Antibody levels decreased significantly in six out of seven patients in the eradication group, while in the follow-up group, the titers declined in only one out of eight patients. In patients with atrophic corpus gastritis, positive serology results may indicate an ongoing infection in spite of negative 13C-UBT and histology results.
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