• Aijing Li, Yuning Pan, Bin Chen, Jianbi Xia, Fang Gan, Yinhua Jin, and Jianjun Zheng.
• Department of Radiology, Ningbo Second Hospital, Ningbo 315010, Zhejiang Province, China.
• Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 May 25; 46 (5): 505-510.

ObjectiveTo investigate the association of parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using reference region model with prognostic factors and molecular subtypes of breast cancer.MethodsMRI and pathological data of 50 patients with pathologically confirmed invasive ductal carcinoma of the breast were retrospectively analyzed. Reference region model was applied to analyze pharmacokinetic quantitative parameters including volume transfer constant (RR Ktrans), rate constant (Kep) and the ratio of Ktrans to extracellular space volume (Ktrans/Ve). The associations of the above parameters with prognostic factors and molecular subtypes of breast cancer were analyzed.ResultsRR Ktrans and Kep were significantly higher in patients of histological grade 3 compared with those of histological grade 1 & 2 (all P<0.05); and the patients with estrogen receptor (ER)-negative and/or progesterone receptor (PR)-negative also had higher RR Ktrans and Kep than those with ER-positive or PR-positive (all P<0.05). For immunohistochemistry, RR Ktrans and Kep were significantly higher in triple negative breast cancer compared with luminal type breast cancer (all P<0.05).ConclusionsHigh RR Ktrans and Kep are associated with poor prognosis of breast cancer, and which can also be used to distinguish molecular subtypes of breast cancer.

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