• Jamie Szczepanski, Ashley Griffin, Sarah Novotny, and Kedra Wallace.
• Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
• Front Med (Lausanne). 2020 Jan 1; 7: 22.

AbstractAcute kidney injury that occurs during pregnancy or in the post-partum period (PR-AKI) is a serious obstetric complication with risk of significant associated maternal and fetal morbidity and mortality. Recent data indicates that the incidence of PR-AKI is increasing, although accurate calculation is limited by the lack of a uniform diagnostic criteria that is validated in pregnancy. Hypertensive and thrombotic microangiopathic disorders of pregnancy have been identified as major contributors to the burden of PR-AKI. As is now accepted regarding preeclampsia, HELLP syndrome and atypical hemolytic uremic syndrome, it is believed that PR-AKI may have long-term renal, cardiovascular and neurocognitive consequences that persist beyond the post-partum period. Further research regarding PR-AKI could be advanced by the development of a pregnancy-specific validated definition and classification system; and the establishment of refined animal models that would allow researchers to further elucidate the mechanisms and sequelae of the disorder.Copyright © 2020 Szczepanski, Griffin, Novotny and Wallace.

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