• J Pediatr Intensive Care · Mar 2018

    Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis.

    • John M Daniel, Philip A Bernard, Sean C Skinner, Prasad Bhandary, Ana Ruzic, Matthew K Bacon, and Hubert O Ballard.
    • Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States.
    • J Pediatr Intensive Care. 2018 Mar 1; 7 (1): 7-13.

    AbstractIn extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates ( n  = 44) who had undergone ECLS for noncardiac indications from 2009 to 2015. Between the two groups (PMP n  = 21, PP n  = 23), the PP oxygenators failed 91% of the time, whereas the PMP oxygenators failed 43% of the time ( p  < 0.05). Analysis suggests PMP oxygenators are less prone to failure than PP oxygenators, and they require fewer number of oxygenator changes during a neonatal ECLS.

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