• Osamu Kainuma, Fumihiko Miura, Daisuke Furukawa, Hiroshi Yamamoto, Akihiro Cho, Keiji Sano, Toshio Nakagohri, and Takehide Asano.
• Department of Gastroenterological Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-ku, Chiba, 260-8717, Japan. okainuma@chiba-cc.jp.
• J Hepatobiliary Pancreat Sci. 2015 Nov 1; 22 (11): 789-94.

BackgroundThe aim of this multi-institutional study was to assess the feasibility and the efficacy of gemcitabine plus cisplatin (CDDP) combination therapy (GC therapy) for biliary tract cancer (BTC) in the adjuvant setting.MethodsEligible patients identified between January 2008 and January 2013 were enrolled. GC therapy at 1,000 mg/m(2) of gemcitabine and 25 mg/m(2) of CDDP on days 1 and 8 repeated every 3 weeks was performed for 6 months. The primary endpoint was the feasibility and the adverse events, and the secondary endpoint was recurrence-free survival (RFS) and overall survival (OS).ResultsAmong 29 evaluable patients, the protocol was completed in 21 (72%) patients. Relative dose intensity (RDI) of gemcitabine and CDDP was 77% and 81%, respectively. There was no difference in the completion rate and the RDI between patients who underwent resection with vs. without major hepatectomy. Grade 3-4 toxicities included leukopenia (14%) and neutropenia (27%). Two-year RFS and 2-year OS was 59% and 90%, respectively.ConclusionsStandard dose of GC therapy is tolerable in patients with BTC who underwent curative resection either with or without major hepatectomy. The survival effect of this regimen is promising, but further comparative study is needed.© 2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

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