• Fabrizio Sallustio, Giacomo Koch, Fana Alemseged, Daniel Konda, Sebastiano Fabiano, Enrico Pampana, Daniele Morosetti, Roberto Gandini, and Marina Diomedi.
• Department of Systems Medicine, Comprehensive Stroke Center, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. fsall75@gmail.com.
• J. Neurol. 2018 Dec 1; 265 (12): 2875-2880.

Objective And DesignWhether combining intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) is superior to mechanical thrombectomy alone for large vessel occlusion acute ischemic stroke is still uncertain. Our aim was to compare the safety and the efficacy of these two therapeutic strategies.MaterialsPatients with acute ischemic stroke secondary to anterior circulation large vessel occlusion.MethodsA retrospective analysis was conducted. IVT was performed with full dose recombinant tissue plasminogen activator. MT alone was performed only if intravenous thrombolysis was contraindicated. Primary outcomes were successful reperfusion, 3-month functional independence, symptomatic intracranial hemorrhage (sICH), and 3-month mortality.Results325 patients were analyzed: 193 treated with combined IVT and MT, 132 with MT alone. The combined treatment group showed higher systolic blood pressure (140 [80-230] vs 150 [90-220]; p = 0.036), rate of good collaterals (55.9% vs 67%; p = 0.03), use of aspiration devices (68.2% vs 79.3%; p = 0.003) and shorter onset-to-reperfusion time (300 [90-845] vs 288 [141-435]; p = 0.008). No differences were found in the efficacy and safety outcomes except for mortality which was lower in the combined treatment group (36.4% vs 25.4%; p = 0.02). However, after multivariable analysis combined treatment was not associated with lower mortality (OR 1.47; 95% CI 0.73-2.96; p = 0.3).ConclusionsOur study suggests that mechanical thrombectomy alone is effective and safe in patients with contraindications to intravenous thrombolysis. Preceding use of IVT in eligible patients was not associated with increased harm or benefit. Randomized controlled trials are needed to clarify whether intravenous thrombolysis before mechanical thrombectomy is associated with additional benefit.

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