• Eur Spine J · Aug 2021

    Observational Study

    Classification of endplate lesions in the lumbar spine and association with risk factors, biochemistry, and genetics.

    • Alessandra Colombini, Fabio Galbusera, Maria Cristina Cortese, Enrico Gallazzi, Marco Viganò, Domenico Albano, Sabina Cauci, Luca Maria Sconfienza, and Marco Brayda-Bruno.
    • Orthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. alessandra.colombini@grupposandonato.it.
    • Eur Spine J. 2021 Aug 1; 30 (8): 223122372231-2237.

    PurposeTo detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.MethodsIn this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2-L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables.ResultsMales showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males).ConclusionsThe markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

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