• Pediatr Hematol Oncol · Mar 2009

    Case Reports

    Rhabdomyolysis due to Escherichia coli sepsis in three pediatric patients with acute lymphoblastic leukemia.

    • Sebnem Yilmaz, Fatih Demircioğlu, Hale Oren, Burçak Güneş, and Gülersu Irken.
    • Department of Pediatric Hematology, Dokuz Eylül University, 35340 Balcova, Izmir, Turkey. sebnem.yilmaz@deu.edu.tr
    • Pediatr Hematol Oncol. 2009 Mar 1; 26 (2): 57-62.

    AbstractRhabdomyolysis with myoglobinuria is an uncommon complication of bacterial sepsis. The authors describe three pediatric acute lymphoblastic leukemia patients who developed rhabdomyolysis during a neutropenic sepsis episode due to Escherichia coli. All of the patients needed hemodynamic supportive treatment because of septic shock. Broad-spectrum antibiotics, alkalinization, and intravenous fluid therapy was given. One patient with renal insufficiency died, despite aggressive treatment. Muscle pain and dark urine color should alert physicians to the possibility of rhabdomyolysis in immunocompromised patients with sepsis. Early and appropriate treatment is critical in these patients to prevent renal failure and shock, and for a better outcome.

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