• Int. J. Infect. Dis. · Dec 2020

    Case Reports

    Favipiravir-induced fever in coronavirus disease 2019: A report of two cases.

    • Hiroyuki Takoi, Yuki Togashi, Daiki Fujimori, Haruki Kaizuka, Shunsuke Otsuki, Takuya Wada, Yoshikazu Takeuchi, and Shinji Abe.
    • Department of Respiratory Medicine, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Tokyo, Japan. Electronic address: taco155485@hotmail.com.
    • Int. J. Infect. Dis. 2020 Dec 1; 101: 188-190.

    AbstractFavipiravir, an antiviral agent, is undergoing clinical trials for treating novel coronavirus disease 2019 (COVID-19). Here, we report two cases of COVID-19 with favipiravir-induced fever. In both cases, pyrexia was observed following the administration of favipiravir despite improvements in symptoms of COVID-19. No other cause for fever was evident after careful physical examination and laboratory investigation. The fever subsided in both patients after the discontinuation of favipiravir. To the best of our knowledge, this is the first report of favipiravir-induced fever in COVID-19 patients.Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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