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- Ryota Horibe, Taku Hatakeyama, Tatsuru Ishikawa, Takeyuki Sawai, Midori Hashimoto, Hiromitsu Domen, Yasunari Takakuwa, Masaaki Satoh, and Kaoru Nishiyama.
- Department of Respiratory Medicine, NTT-East Corporation Sapporo Medical Center, Japan.
- Intern. Med. 2022 Feb 1; 61 (3): 401-405.
AbstractA 78-year-old woman with multiple lung nodules, epithelial growth factor receptor (EGFR) exon 20 insertion mutations, and diagnosed with advanced lung adenocarcinoma (cT4N3M1a, stage IVA), was referred to our hospital. She received immune checkpoint inhibitor (ICI) therapy. The therapy showed remarkable antitumor effects; only a single nodule remained in the right upper lobe. The nodule was diagnosed as adenocarcinoma through a biopsy. We subsequently performed right upper lobectomy for multiple primary lung cancer (MPLC). The surgical specimen contained EGFR exon 19 deletion mutations and not exon 20 insertion mutations.
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