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JPEN J Parenter Enteral Nutr · Sep 2015
ReviewPast, Present, and Future of Lipid Resuscitation Therapy.
- Michael R Fettiplace and Guy Weinberg.
- Department of Anesthesiology, University of Illinois College of Medicine, Chicago, Illinois Research & Development Service, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois Neuroscience Program, University of Illinois at Chicago, Chicago, Illinois mfetti3@uic.edu.
- JPEN J Parenter Enteral Nutr. 2015 Sep 1; 39 (1 Suppl): 72S-83S.
AbstractLipid resuscitation therapy was identified in 1998 as an effective treatment for local anesthetic systemic toxicity in an animal model. Since the original observation, the field has progressed tremendously with successful clinical translation and expansion of use to treatment of other types of drug overdose. Recent work has expanded our understanding of the mechanism of this novel treatment, one that includes both a dynamic scavenging component and direct cardiotonic effect. In this review, we discuss the past, present, and future of lipid resuscitation therapy with a focus on our understanding of the mechanism and directions that the field is moving, both from a clinical and basic research side. © 2015 American Society for Parenteral and Enteral Nutrition.
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