• J. Neurosci. · Nov 2017

    Review

    In Vivo Imaging of CNS Injury and Disease.

    • Katerina Akassoglou, Mario Merlini, Victoria A Rafalski, Raquel Real, Liang Liang, Yunju Jin, Sarah E Dougherty, De PaolaVincenzoV0000-0001-9987-8291Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom., David J Linden, Thomas Misgeld, and Binhai Zheng.
    • Gladstone Institutes; San Francisco, California 94158, katerina.akassoglou@gladstone.ucsf.edu bizheng@ucsd.edu.
    • J. Neurosci. 2017 Nov 8; 37 (45): 10808-10816.

    AbstractIn vivo optical imaging has emerged as a powerful tool with which to study cellular responses to injury and disease in the mammalian CNS. Important new insights have emerged regarding axonal degeneration and regeneration, glial responses and neuroinflammation, changes in the neurovascular unit, and, more recently, neural transplantations. Accompanying a 2017 SfN Mini-Symposium, here, we discuss selected recent advances in understanding the neuronal, glial, and other cellular responses to CNS injury and disease with in vivo imaging of the rodent brain or spinal cord. We anticipate that in vivo optical imaging will continue to be at the forefront of breakthrough discoveries of fundamental mechanisms and therapies for CNS injury and disease.Copyright © 2017 the authors 0270-6474/17/3710808-09$15.00/0.

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