• Curr. Opin. Biotechnol. · Aug 2018

    Review

    Genome engineering for CNS injury and disease.

    • Jennifer Pardieck and Shelly Sakiyama-Elbert.
    • Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
    • Curr. Opin. Biotechnol. 2018 Aug 1; 52: 89-94.

    AbstractRecent developments in genome engineering methods have advanced our knowledge of central nervous system (CNS) function in both normal health and following disease or injury. This review discusses current literature using gene editing tools in CNS disease and injury research, such as improving viral-mediated targeting of cell populations, generating new methods for genome editing, reprogramming cells into CNS cell types, and using organoids as models of development and disease. Readers may gain inspiration for continuing research into new genome engineering methods and for therapies for CNS applications.Copyright © 2018 Elsevier Ltd. All rights reserved.

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