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- Monica M Mita and Anthony W Tolcher.
- Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX 78230, USA. mmita@idd.org
- Curr Oncol Rep. 2007 Jul 1; 9 (4): 316-22.
AbstractBone and soft tissue sarcomas represent rare tumors that can be cured by local treatment at early stages of disease. However, advanced or metastatic disease is rarely cured, and very few drugs have shown efficacy in this setting. Early studies with mTOR inhibitors have demonstrated antitumor activity in patients with metastatic sarcoma who failed previous chemotherapies. The response rate and durable stable disease in early studies, as well as the tolerability profile, recommend these drugs as promising candidates for further clinical studies. This article discusses preliminary results from clinical trials in patients with advanced or metastatic sarcoma as well as future perspectives.
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