• H He and Y Xie.
• Department of Nephrology, Minhang Hospital, Fudan University, Shanghai; Department of Geriatrics, First Affiliated Hospital of Soochow University, Suzhou, China.
• Niger J Clin Pract. 2021 Aug 1; 24 (8): 1133-1137.

AimsTo investigate alteration of intestinal microflora in uremia patients with or without blood purification treatments.MethodsThe present study included a total of 109 adult patients who were administered in our hospital during 2014 August to 2015 December, 85 cases had already received hemodialysis treatment and 24 cases had not received any renal transplantation treatments. Serum levels of hemoglobin, albumin, creatinine, hypersensitive C reactive protein, and cystatin C, as well as blood urea nitrogen and estimated glomerular filtration rate were determined. 16S rRNA sequencing was conducted to determine the levels of Bifidobacterium, Lactobacillus acidophilus, Escherichia coli, and Enterococcus faecalis.ResultsThe hemoglobin level in the hemodialysis group was significantly higher than that of the non-hemodialysis patients. The levels of Bifidobacterium and Lactobacillus acidophilus were significantly lower while the levels of Escherichia coli and Enterococcus faecalis were significantly higher in both of the patient groups compared with the healthy control. In all treatment groups, levels of Bifidobacterium and Lactobacillus acidophilus were significantly higher and levels of Escherichia coli and Enterococcus faecalis were significantly lower compared with the non-blood purification treatment group.ConclusionsThe intestinal microflora might be influenced by uremia and might also be affected by blood purification treatments.

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