• Medicina clinica · Feb 2022

    Review

    Pulmonary involvement in Sjögren's syndrome.

    • Jaume Mestre-Torres and Roser Solans-Laque.
    • Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Hospital Vall d'Hebron, Barcelona, España; Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, España. Electronic address: jmestre@vhebron.net.
    • Med Clin (Barc). 2022 Feb 25; 158 (4): 181-185.

    AbstractSjögren's syndrome is an autoimmune disease that involves exocrine glands. The most characteristic symptoms consist of the sicca syndrome (including xerostomia and dry eye - xerophtalmia), but can involve multiple organs. The extraglandular involvement determines the prognosis. It is typically associated with the presence of antinuclear antibodies, including Ro-60 antibodies. Pulmonary involvement appears as bronchiectasis and/or interstitial pneumonia. Considering its high prevalence, it must be ruled out in all patients with respiratory symptoms by performing pulmonary function tests and high-resolution computed tomography of the chest. Evaluation can be completed with a transbronchial biopsy if diagnostic doubts persist. Treatment includes steroid therapy, inmunosupressive or antifibrotic drugs, or biological therapy. In selected cases pulmonary transplantation must be considered.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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