• Carmen Patino-Alonso, Marta Gómez-Sánchez, Jesús M Hernández-Rivas, José R González-Porras, José M Bastida-Bermejo, Ana-Africa Martín, Emiliano Rodríguez-Sánchez, José I Recio-Rodríguez, Jesús González-Sánchez, José A Maderuelo-Fernández, Luis García-Ortiz, and Manuel A Gómez-Marcos.
• Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), 37005 Salamanca, Spain; Department of Statistics, University of Salamanca, Salamanca, Spain. Electronic address: carpatino@usal.es.
• Med Clin (Barc). 2022 Jun 10; 158 (11): 503-508.

PurposeTo assess whether subjects with Philadelphia negative myeloproliferative neoplasms (Ph-MPNs) show differences in the presence of vascular, cardiac or renal target organ damage (TOD) and other vascular function parameters as compared to individuals without this condition.MethodsAn observational study was conducted. Fifty-seven subjects diagnosed with Ph-MPNs used as cases and 114 subjects without Ph-MPNs as controls. We matched the subjects with and without Ph-MPNs using the propensity scores in a 1:2 ratio using the variables gender, type 2 diabetes mellitus, high blood pressure, hyperlipidaemia and smoking. Vascular, cardiac and renal TOD were established according to the criteria of the European Society of Hypertension and Cardiology guidelines. Arterial stiffness was also assessed using the cardio-ankle vascular index (CAVI).ResultsMean age was 63.50±11.70 and 62.90±8.32 years in subjects with and without Ph-MPNs, 32 females (56%) in the first group and 62 (54%) in the second. Subjects with Ph-MPNs have a higher percentage of carotid injury than subjects without Ph-MPNs (35.1% vs. 21.1%) and higher albumin/creatinine ratio. In the logistic regression analysis, subjects with Ph-MPNs had an OR=2.382 (IC95% 1.066-5.323) for carotid injury versus those without haematological disease.ConclusionsSubjects with Ph-MPNs have twice the risk of by carotid injury than those without haematological disease.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

19 keywords...

hide…