• Xue Liu, Shuang Wang, Yi Liu, Li Juan Liu, Yan Yun Lv, Ping Tang, Jost B Jonas, and Liang Xu.
• Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China.
• Acta Ophthalmol. 2017 Feb 1; 95 (1): e54-e61.

PurposeTo study the retinal oxygen saturation in normal eyes of Chinese adolescents.MethodsPerforming retinal oximetry with the Oxymap T1 Retinal Oximeter in healthy children and adolescents (aged 5-18 years old), we measured the arterial (SaO2 ) and venular (SvO2 ) oxygen saturation and the arteriovenous difference in oxygen saturation (Sa-vO2 ).ResultsThe study included 122 individuals with a mean age of 13.0 ± 2.9 years (range: 5-18 years) and a mean refractive error of -3.25 ± 2.49 dioptres (range:-8.88 to +3.13 dioptres). Mean SaO2 , SvO2 and Sa-vO2 was 85.5 ± 7.1%, 48.2 ± 5.5% and 37.3 ± 6.5%, respectively. Mean SaO2 was significantly (p < 0.001) the lowest in the inferotemporal quadrant (79.1 ± 9.0%), followed by the superotemporal quadrant (83.4 ± 9.7%), the inferonasal quadrant (90.4 ± 10.6%) and the superonasal quadrant (93.4 ± 10.8%). In a similar manner, the values of the SvO2 were the lowest (p < 0.001) in the inferotemporal quadrant (42.1 ± 8.3%), followed by the superotemporal quadrant (47.8 ± 7.2%), the inferonasal quadrant (52.3 ± 8.4%) and the superonasal quadrant (55.1 ± 7.6%). Arteriovenous difference in oxygen saturation (Sa-vO2 ) did not differ significantly (all p > 0.05) between the fundus quadrants. In multiple linear regression analysis, SaO2 increased (regression coefficient r2  = 0.28) with older age (standardized regression coefficient β: 0.23; p = 0.01) and more myopic refractive error (β: -0.39; p < 0.001). Higher SvO2 was significantly correlated with more myopic refractive error (β: -0.46; p < 0.001; r2  = 0.20), while Sa-vO2 increased significantly only with older age in the multivariate analysis (β: 0.26; p = 0.01; r2  = 0.07).ConclusionsOur study provides normative data for Chinese children and adolescents who showed lower values than adults for SaO2 and SvO2 . SaO2 increased with older age and higher myopic refractive error, SvO2 increased with higher myopic refractive error, and Sa-vO2 increased with older age.© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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