• Neil M Bressler, Wesley T Beaulieu, Maureen G Maguire, Adam R Glassman, Kevin J Blinder, Susan B Bressler, Victor H Gonzalez, Lee M Jampol, Michele Melia, Jennifer K Sun, John A Wells, and Diabetic Retinopathy Clinical Research Network.
• Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
• Am. J. Ophthalmol. 2018 Nov 1; 195: 93-100.

PurposeAssess associations of 2-year visual acuity (VA) outcomes with VA and optical coherence tomography central subfield thickness (CST) after 12 weeks of anti-vascular endothelial growth factor treatment for diabetic macular edema in DRCR.net Protocol T.DesignRandomized clinical trial.MethodsSetting: Multicenter (89 U.S. sites).Patient PopulationEyes with VA and CST data from baseline and 12-week visits (616 of 660 eyes randomized [93.3%]).InterventionSix monthly injections of 2.0 mg aflibercept, 1.25 mg bevacizumab, or 0.3 mg ranibizumab; subsequent injections and focal/grid laser as needed for stability.Main Outcome MeasuresChange in VA from baseline and VA letter score at 2 years.ResultsTwelve-week VA response was associated with 2-year change in VA and 2-year VA letter score for each drug (P < .001) but with substantial individual variability (multivariable R2 = 0.38, 0.29, and 0.26 for 2-year change with aflibercept, bevacizumab, and ranibizumab, respectively). Among eyes with less than 5-letter gain at 12 weeks, the percentages of eyes gaining 10 or more letters from baseline at 2 years were 42% (20 of 48), 31% (21 of 68), and 47% (28 of 59), and median 2-year VA was 20/32, 20/32, and 20/25, in the aflibercept, bevacizumab, and ranibizumab groups, respectively. Twelve-week CST response was not strongly associated with 2-year outcomes.ConclusionsA suboptimal response at 12 weeks did not preclude meaningful vision improvement (ie, ≥ 10-letter gain) in many eyes at 2 years. Eyes with less than 5-letter gain at 12 weeks often had good VA at 2 years without switching therapies.Copyright © 2018 Elsevier Inc. All rights reserved.

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