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Expert Opin Ther Pat · Jul 2016
ReviewCannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.
- Paula Morales, Laura Hernandez-Folgado, Pilar Goya, and Nadine Jagerovic.
- a Instituto de Química Médica , Consejo Superior de Investigaciones Científicas , Madrid , Spain.
- Expert Opin Ther Pat. 2016 Jul 1; 26 (7): 843-56.
IntroductionModulation of the CB2 receptor is an interesting approach for pain and inflammation, arthritis, addictions, neuroprotection, and cancer, among other possible therapeutic applications, and is devoid of central side effects.Areas CoveredThis review highlights the novel scaffolds for CB2 ligands and the diverse therapeutic applications for CB2 modulators disclosed in patents published since 2012.Expert OpinionStructural diversity of CB2 modulator scaffolds characterized the patent literature. Several CB2 agonists reached clinical Phase II for pain management and inflammation. Other therapeutic applications need to be explored such as neuroprotection and/or neurodegeneration.
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