• Heinz-Herbert Homann, Oliver Rosbach, Wiebke Moll, Peter Maria Vogt, Guenter Germann, Michael Hopp, Birgit Langer-Brauburger, Karen Reimer, and Hans-Ulrich Steinau.
• Department of Plastic Surgery, Hand Surgery and Burn Unit, University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany. Heinz.Homann@rub.de
• Ann Plast Surg. 2007 Oct 1; 59 (4): 423-7.

AbstractLocal treatment of burn injuries with conventional anti-infective preparations does not provide the moist environment that promotes fast wound healing. In a randomized controlled trial the effects of liposome polyvinyl-pyrrolidone-iodine (PVP-I) hydrogel, a novel formulation of PVP-I in a liposome hydrogel with high water-binding capacity, were investigated in 43 patients with partial-thickness burn wounds in an intraindividual comparison with a conventional silver-sulfadiazine cream. Treatment with liposome PVP-I hydrogel resulted in significantly faster complete healing of the burn wounds compared with silver-sulfadiazine cream (9.9 +/- 4.5 days versus 11.3 +/- 4.9; P < 0.015). The cosmetic result (smoothness, elasticity, appearance) was rated as excellent for 37.0% of study wounds with liposome PVP-I hydrogel compared with 13.0% of wounds treated with silver-sulfadiazine cream. Local tolerability was good; handling and change of dressing were rated as easy. Local treatment with liposome PVP-I hydrogel thus provides fast wound healing with a favorable cosmetic result.

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