[Possible clinical potential in reverting muscular block with

Ugeskrift for laeger · Feb 2013

Review

[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].

Neuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of sugammadex - an antidote to the NMB rocuronium - which within 1-3 minutes neutralizes the effects of rocuronium. High-dose rocuronium is now an alternative to suxamethonium in acute or short procedures and in a situation, where ventilation/intubating cannot be performed, sugammadex can reverse the rocuronium blockade within minutes.

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- Emilie Øberg and Casper Claudius.
- Anæstesiologisk Afdeling, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. emilieberthelsen@hotmail.com
- Ugeskr. Laeg. 2013 Feb 11;175(7):428-32.
AbstractNeuromuscular blockers (NMBs) provide good conditions for endotracheal intubation and surgery. NMBs have been associated with higher morbidity and mortality, mainly due to post-operative residual neuromuscular block. This may become history with the advent of sugammadex - an antidote to the NMB rocuronium - which within 1-3 minutes neutralizes the effects of rocuronium. High-dose rocuronium is now an alternative to suxamethonium in acute or short procedures and in a situation, where ventilation/intubating cannot be performed, sugammadex can reverse the rocuronium blockade within minutes.

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[Possible clinical potential in reverting muscular block with sugammadex in anaesthesia and surgery].

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