• Junzo Takeda, Hiroshi Iwasaki, Tetsutaro Otagiri, Takasumi Katoh, Koh Shingu, Hidefumi Obara, Hideki Nakatsuka, Yoshinobu Tomiyama, and Toshiharu Kasaba.
• Masui. 2014 Oct 1;63(10):1083-8.

BackgroundEfficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients.MethodsWe studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg . kg-1 of sugammadex was administered. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.ResultsFor the rocuronium-induced neuromuscular block, the mean recovery time of the T4/T1 ratio to 0.9 decreased from 66.9 min in the sugammadex 0.5 mg kg-1 group to 1.3 min in the sugammadex 8.0 mg kg-1 group. For the vecuronium-induced neuromuscular block it decreased from 79.5 min in the sugammadex 0.5 mg . kg-1 group to 2.9 min in the sugammadex 8.0 mg . kg-1 group. No clinical evidence of recurarization or residual curarization was observed.ConclusionsThe efficacy and safety of sugammadex were confirmed in Japanese surgical patients for reversal from deep block.

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