• Rev Assoc Med Bras (1992) · Feb 2021

    New papulovesicular rash in the course of COVID-19 signaling viral reactivation.

    • Marcos Frata Rihl, Lúcia Costa Cabral Fendt, and Wagner Luis Nedel.
    • Hospital de Clínicas de Porto Alegre, Intensive Care Unit - Porto Alegre (RS), Brazil.
    • Rev Assoc Med Bras (1992). 2021 Feb 1; 67 (2): 182-184.

    AbstractCutaneous manifestations are considered an infrequent presentation of coronavirus disease 2019 (COVID-19) and are mostly described in outpatient settings. Its onset during the course of the severe COVID-19 disease has been poorly described in severe cases. Studies focused on dermatological manifestations mostly described maculopapular or pernio-like lesions and less frequently vesicular or varicella-like eruption. We described the occurrence of a vesiculopapular eruption in three laboratory-confirmed COVID-19 patients associated with severe lung injury in whom the skin findings preceded viral reactivation and recrudescence of hypoxemia. The potential mechanisms for COVID-19-related cutaneous manifestations include immune hypersensitivity, cytokine-release syndrome, deposition of microthrombi, and vasculitis.

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