• Carlos Alberto Nogueira-de-Almeida, Luiz Antonio Del Ciampo, Ivan Savioli Ferraz, Ieda Regina Lopes Del Ciampo, Andrea Aparecida Contini, and Fábio da Veiga Ued.
• Universidade Federal de São Carlos, Medicine Department - São Carlos (SP), Brazil.
• Rev Assoc Med Bras (1992). 2021 Jan 1; 67Suppl 1 (Suppl 1): 115-120.

ObjectiveTo identify epidemiological and clinical characteristics of multisystemic inflammatory syndrome associated with coronavirus infection as one of the severe forms of COVID-19 involvement in children and adolescents.Methodsreview was based on articles published in 2020 in the PubMed, Medline, Scopus, SciELO and Cochrane databases.SummaryMultisystemic inflammatory syndrome is a serious clinical disorder that affects children and adolescents and is associated with the detection of previous exposure to SARS-CoV-2. It is characterized by the installation of a shock picture, with a significant increase in inflammatory markers such as presentations of Kawasaki Disease or shock syndrome related to Kawasaki Disease, or even toxic shock syndrome, with the clinical picture being characterized by fever of difficult control, rash, conjunctivitis, peripheral edema, generalized pain in the extremities and gastrointestinal symptoms.ConclusionsAlthough the vast majority of children with COVID-19 have mild symptoms, it is necessary to consider that some have a hyperinflammatory response. It is essential that health professionals receive information that can assist in the recognition of this clinical condition, differentiating it from other diagnoses, so that early and appropriate treatment is instituted.

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