• Wang Chun, Deng Chao, Han Qi, Zhu Dongliang, Li Zhenmei, and Li Jia.
• Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei.
• Medicine (Baltimore). 2021 Aug 6; 100 (31): e26678e26678.

BackgroundAlthough nonpharmacological therapies are recommended as first-line treatments for insomnia, they do not widely implement in practice owing to costly or time-consuming. As a result, pharmacotherapy remains to be commonly prescribed for patients with the sleep disorder. Pharmacotherapy for insomnia consists of different types of drugs. Few studies focused on comprehensively evaluating all available drugs for insomnia. Our review aims to compare efficacy and safety of pharmacological and nonpharmacological treatments by synthesizing direct evidence and indirect evidence to help clinicians and patients make informed decisions for insomnia.MethodsWe will search the MEDLINE, EMBASE, and Cochrane Register of Controlled Trials between January 2000 and June 12, 2021. Randomized controlled trials of pharmacological and nonpharmacological interventions for insomnia will be included. Study quality will be assessed on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Eight network meta-analyses were conducted. A Bayesian network meta-analysis would be performed, and relative ranking of agents would be assessed. A node splitting method will be used to examine the inconsistency between direct and indirect comparisons when a loop connecting 3 arms exists.ResultsThe results of this paper will be submitted to a peer-reviewed journal for publication.ConclusionThe conclusion of our study will provide updated evidence to rank the effectiveness and safety of pharmacological and nonpharmacological interventions for insomnia.Ethics And DisseminationEthical approval is not applicable, as this study is a network meta-analysis based on published trials.Inplasy Registration NumberINPLASY202160031.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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