• Zihao Guo, Jiali Jiang, Hao Wu, Jinxia Zhu, Shutian Zhang, and Chuan Zhang.
• Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.
• Medicine (Baltimore). 2021 Aug 13; 100 (32): e26756.

BackgroundA rapid lateral flow test (Peptest) to detect pepsin in saliva/sputum has been considered as a valuable method for diagnosing laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD). The aim of this meta-analysis is to analyze the utility of Peptest for diagnosis of LPR and GERD.MethodsPubMed, EMBASE, and the Cochran Library (from January 1980 to 26 January 2020) were searched for pepsin in saliva for LPR/GERD diagnosis. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve data were summarized to examine the accuracy.ResultsA total of 16 articles that included 2401 patients and 897 controls were analyzed. The pooled sensitivity and specificity for the diagnosis of GERD/LPR with Peptest were 62% (95% confidence interval [CI] 49%-73%) and 74% (95% CI 50%-90%), respectively. The summarized diagnostic odds ratio and area under the curve were 5.0 (95% CI 2-19) and 0.70 (95% CI 0.66-0.74), respectively.ConclusionPeptest shows moderate diagnostic value for LPR and GERD. More studies with standard protocols should be done to verify its usefulness.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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