• Lingyan Zhao, Ping Shi, Xiaomin Xiong, and Jia Zeng.
• Respiratory and Critical Care Medicinen, Guangyuan Central Hospital, Guangyuan, Sichuan province, China.
• Medicine (Baltimore). 2021 Aug 13; 100 (32): e26864e26864.

BackgroundLung cancer is one of the most common cancers, the symptoms and treatment of which can cause negative emotions like anxiety, depression, and cancer-related fatigue (CRF). Nonpharmacological interventions, serving as alternative therapies, can greatly alleviate CRF in lung cancer patients. Previous meta-analyses have reported nonpharmacological interventions of CRF in lung cancer patients, but the results may be conflicting, and the reporting and methodological qualities remain unknown. Moreover, there is limited evidence to identify efficient and safe non-pharmacological interventions of CRF in lung cancer patients. This study aims to assess the therapeutic efficacy of nonpharmacological interventions of CRF in lung cancer patients through a network meta-analysis.MethodsRelevant literatures reporting non-pharmacological interventions of CRF in lung cancer patients published before June 2021 will be searched in online databases, including Wanfang, VP Information Chinese Journal Service Platform, China National Knowledge Infrastructure, Chinese BioMedicine Literature Database, PubMed, Embase, Cochrane, and Web of science. Two reviewers will be independently responsible for study selection, quality appraisal, and data extraction. Data analysis will be performed using the STATA14.0 and GEMTC 0.14.3 software.ResultsThis meta-analysis will provide additional and stronger evidences for nonpharmacological interventions of CRF in lung cancer patients. Our findings will be conductive to make therapeutic decisions by clinicians.ConclusionThis study will provide a reliable evidence-based basis for non-pharmacological interventions of CRF in lung cancer patients.Ethics And DisseminationEthical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. This review would be disseminated in a peer-reviewed journal or conference presentations.Osf Registration NumberDOI 10.17605/OSF.IO/QRY42.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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