• Medicine · Aug 2021

    Multicenter Study Observational Study

    Improved and new-onset anemia during follow-up in patients with acute decompensated heart failure: Characteristics and outcomes.

    • Yuta Seko, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura, and KCHF Study Investigators.
    • Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    • Medicine (Baltimore). 2021 Aug 13; 100 (32): e26892.

    AbstractThere was no previous report on the prognostic impact of new-onset or improved anemia after discharge from acute decompensated heart failure (ADHF).We analyzed 771 patients with ADHF and who were followed in multicenters in Japan was divided into 4 groups based on the hemoglobin values at discharge and 6-month index visit: 373 patients (48.4%) with persistent anemia, 87 patients (11.3%) with new-onset anemia, 91 patients (11.8%) with improved anemia, and 220 patients (28.5%) without anemia.The primary outcome measure was a composite of all-cause death or HF hospitalization after index visit. The cumulative 6-month incidences of the primary outcome measure were 25.2% for persistent anemia, 18.5% for new onset anemia, 9.0% for improved anemia, and 9.2% for no anemia (log-rank P < .001). Compared with the no anemia group, the excess risk for the primary outcome measure remained significant in the persistent anemia group [hazard ratio (HR) 2.70, 95% confidence interval (95% CI), 1.45-5.44, P = .001] and in the new-onset anemia group (HR 2.73, 95% CI 1.19-6.25, P = .02), while it was not significant in the improved anemia group (HR 1.69, 95% CI 0.68-4.03, P = .25).Persistent and new-onset anemia at 6-month visit were associated with a subsequent higher risk for all-cause death or HF hospitalization in patients with ADHF, suggesting the importance of detecting anemia during follow-up.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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