• Lizhu Liu, Xinbo Zhang, Chaoyi Li, and Ye Qu.
• Department of Traumatic Surgery, The Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan Province, China.
• Medicine (Baltimore). 2021 Aug 13; 100 (32): e26923e26923.

BackgroundThe function of Angipoietin-2 (Agn2) in osteosarcoma has not been fully explored and exists controversial. Therefore, we conducted a meta-analysis to investigate the role of Agn2 in the prognosis of osteosarcoma. In addition, bioinformatics analysis was carried out to reveal the mechanism and related pathways of Agn2 in osteosarcoma.MethodsLiterature search was operated on databases up to July 2021, including PubMed, Web of Science, China National Knowledge Infrastructure, China Biology Medicine disc, and Wan Fang Data. The relation between Agn2 expression and survival outcome was estimated by hazard ratio and 95% confidence interval. Meta-analysis was performed on the Stata 16.0. Being obtained from The Cancer Genome Atlas, the original data were used to further verify the prognostic role of Agn2 in osteosarcoma. Gene set enrichment analysis was applied to predict the potential mechanism of Agn2. The correlation between Agn2 and osteosarcoma immune infiltration was analyzed by TIMER database.ResultsThe results of this meta-analysis would be submitted to peer-reviewed journals for publication.ConclusionThis study will provide evidence for the exploration of the relationship between Agn2 and the prognosis of osteosarcoma and its mechanism.Ethics And DisseminationThe private information from individuals will not be published. This systematic review also should not damage participants' rights. Ethical approval is not available. The results will be published in a peer-reviewed journal or disseminated in relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/GWQ53.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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