• Jialu Wang, Shidong Liu, Xiangxiang Han, Zunhui Wan, Yang Chen, Hao Chen, and Bing Song.
• The First Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou, China.
• Medicine (Baltimore). 2021 Jul 23; 100 (29): e26696e26696.

BackgroundThe prognosis of patients with aortic stenosis, in conjunction with chronic kidney disease (CKD), after transcatheter aortic valve replacement (TAVR) remains unclear. This study assessed the impact of CKD, and different stages of CKD, on prognosis of patients undergoing TAVR.MethodsThe protocol was written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement guidelines. As of June 2021, we performed a comprehensive literature search on studies related to CKD and TAVR, using databases such as PubMed, Embase, Cochrane Library, and Web of Science. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Then, Stata 15.0 software was used for meta-analysis.Results And ConclusionThe purpose of this study was to evaluate the effect of CKD and different stages of CKD on the prognosis of patients with TAVR. It is hoped to provide a comprehensive reference for clinical practice and related clinical trials in the future.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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