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J. Clin. Microbiol. · Jan 2021
Detection of SARS-CoV-2 Antibodies in Oral Fluid Obtained Using a Rapid Collection Device.
- Melanie A MacMullan, Prithivi Chellamuthu, Aubree Mades, Sudipta Das, Fred Turner, Vladimir I Slepnev, and Albina Ibrayeva.
- Curative Inc., San Dimas, California, USA.
- J. Clin. Microbiol. 2021 Jan 21; 59 (2).
AbstractCurrent commercially available methods for reliably detecting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain expensive and inaccessible due to the need for whole-blood collection by highly trained phlebotomists using personal protective equipment (PPE). We have evaluated an antibody detection approach using the OraSure Technologies oral antibody collection device (OACD) and their proprietary SARS-CoV-2 total antibody detection enzyme-linked immunosorbent assay (ELISA). We found that the OraSure test for total antibody detection in oral fluid had comparable sensitivity and specificity to commercially available serum-based ELISAs for SARS-CoV-2 antibody detection while allowing for a more accessible form of specimen collection with the potential for self-collection.Copyright © 2021 American Society for Microbiology.
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