• Diagn. Microbiol. Infect. Dis. · May 2020

    In Vitro Activity of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacilli Isolated from Patients in Canadian Intensive Care Units.

    • Alyssa R Golden, Heather J Adam, Melanie Baxter, Andrew Walkty, Philippe Lagacé-Wiens, James A Karlowsky, and George G Zhanel.
    • Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 727 McDermot Avenue, Winnipeg, Manitoba, R3E 3P5, Canada. Electronic address: alyssa.golden@umanitoba.ca.
    • Diagn. Microbiol. Infect. Dis. 2020 May 1; 97 (1): 115012.

    AbstractThe in vitro activity of cefiderocol was evaluated against Gram-negative bacilli isolated from patients in Canadian intensive care units from 2015 to 2017 using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method and interpretive criteria. All 800 isolates of Gram-negative bacilli tested were susceptible to cefiderocol (MIC ≤4 μg/ml), including isolates of ESBL-producing (n=40), AmpC-producing (n=6), and carbapenem-nonsusceptible (n=21) Enterobacterales, carbapenem-nonsusceptible (n=54) and multidrug-resistant (n=29) Pseudomonas aeruginosa, Stenotrophomonas maltophilia (n=66), and Acinetobacter baumannii (n=11).Copyright © 2020 Elsevier Inc. All rights reserved.

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