• Internal medicine journal · Feb 2014

    Case Reports

    Two-faced haemophagocytic lymphohistiocytosis: comparative review of two cases of adult haemophagocytic lymphohistiocytosis.

    • E Mayson, J Saverimuttu, and P Warburton.
    • Haematology Department, Wollongong Hospital, Wollongong, New South Wales, Australia.
    • Intern Med J. 2014 Feb 1; 44 (2): 198-201.

    AbstractHaemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of children and adults. Cytokine dysfunction, uncontrolled accumulation of activated T-cells and histiocytes, and the inability to terminate the immune response lead to the clinical manifestations of extreme inflammation and end-organ damage. HLH is notoriously underreported because of its ability to mimic many other common diseases. Here, we outline two cases of HLH, one primary and the other secondary, to highlight some of the differences and to discuss therapeutic principles and emerging concepts. © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.

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