• Critical care clinics · Jul 2009

    Review

    Sedation and weaning from mechanical ventilation: linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomes.

    • Michael H Hooper and Timothy D Girard.
    • Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA. michael.hooper@vanderbilt.edu
    • Crit Care Clin. 2009 Jul 1;25(3):515-25, viii.

    AbstractLiberation from mechanical ventilation is a vital treatment goal in the management of critically ill patients. The duration of mechanical ventilation is affected by strategies for ventilator weaning and sedation. The authors review literature on weaning from mechanical ventilation and delivery of sedation in critically ill patients, including current guidelines recommending the use of spontaneous breathing trials and spontaneous awakening trials. Implementation of these strategies in a wake-up-and-breathe protocol has demonstrated benefit over the use of spontaneous breathing trials alone.

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