• Antonio Ramos-Martínez, Lina Marcela Parra-Ramírez, Ignacio Morrás, María Carnevali, Lorena Jiménez-Ibañez, Manuel Rubio-Rivas, Francisco Arnalich, José Luis Beato, Daniel Monge, Uxua Asín, Carmen Suárez, Santiago Jesús Freire, Manuel Méndez-Bailón, Isabel Perales, José Loureiro-Amigo, Ana Belén Gómez-Belda, Paula María Pesqueira, Ricardo Gómez-Huelgas, Carmen Mella, Luis Felipe Díez-García, Joaquim Fernández-Sola, Ruth González-Ferrer, Marina Aroza, Juan Miguel Antón-Santos, and BermejoCarlos LumbrerasCLInternal Medicine Department, 12 de Octubre University Hospital, Av. de Córdoba, s/n, 28041, Madrid, Spain..
• Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda UAM, IDIPHSA, Maestro Rodrigo 2, 28222, Majadahonda, Madrid, Spain. aramos220@gmail.com.
• Sci Rep. 2021 Jul 2; 11 (1): 13733.

AbstractTo determine the proportion of patients with COVID-19 who were readmitted to the hospital and the most common causes and the factors associated with readmission. Multicenter nationwide cohort study in Spain. Patients included in the study were admitted to 147 hospitals from March 1 to April 30, 2020. Readmission was defined as a new hospital admission during the 30 days after discharge. Emergency department visits after discharge were not considered readmission. During the study period 8392 patients were admitted to hospitals participating in the SEMI-COVID-19 network. 298 patients (4.2%) out of 7137 patients were readmitted after being discharged. 1541 (17.7%) died during the index admission and 35 died during hospital readmission (11.7%, p = 0.007). The median time from discharge to readmission was 7 days (IQR 3-15 days). The most frequent causes of hospital readmission were worsening of previous pneumonia (54%), bacterial infection (13%), venous thromboembolism (5%), and heart failure (5%). Age [odds ratio (OR): 1.02; 95% confident interval (95% CI): 1.01-1.03], age-adjusted Charlson comorbidity index score (OR: 1.13; 95% CI: 1.06-1.21), chronic obstructive pulmonary disease (OR: 1.84; 95% CI: 1.26-2.69), asthma (OR: 1.52; 95% CI: 1.04-2.22), hemoglobin level at admission (OR: 0.92; 95% CI: 0.86-0.99), ground-glass opacification at admission (OR: 0.86; 95% CI:0.76-0.98) and glucocorticoid treatment (OR: 1.29; 95% CI: 1.00-1.66) were independently associated with hospital readmission. The rate of readmission after hospital discharge for COVID-19 was low. Advanced age and comorbidity were associated with increased risk of readmission.

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