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- Celeste De Jager, Andrew D Blackwell, Marc M Budge, and Barbara J Sahakian.
- OPTIMA, University of Oxford, Dept. of Pharmacology, Oxford, UK.
- Am J Geriatr Psychiatry. 2005 Aug 1; 13 (8): 735-40.
ObjectiveAuthors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline.MethodsA group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD).ResultsBaseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD.ConclusionCognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
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